Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.D50E

c.150C>A

Surrounding Variants

1 paper

NM_003000.3

p.D50D

c.150C>T

1 paper

NM_003000.3

p.D50E

c.150C>G

3 papers

NM_003000.3

p.D50insFs

c.149dupA

1 paper

NM_003000.3

p.K51*

c.151A>T

1 paper

NM_003000.3

p.D50V

c.149A>T

5 papers

NM_003000.3

p.D50G

c.149A>G

2 papers

NM_003000.3

p.D50Y

c.148G>T

1 paper

NM_003000.3

p.P49insFs

c.147dupA

1 paper

NM_003000.3

p.D50H

c.148G>C

2 papers

NM_003000.3

p.D50_K51insFs

c.148_151dup4

3 papers

NM_003000.3

p.K51fs

c.151_152fs

1 paper

NM_003000.3

p.K51delFs

c.151_152delTT