Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.P49S

c.145C>T

Surrounding Variants

2 papers

NM_003000.3

p.D48insFs

c.143_144dupAC

1 paper

NM_003000.3

p.D48fs

c.142_143fs

30 papers

NM_003000.3

p.D48V

c.143A>T

2 papers

NM_003000.3

p.P49P

c.147A>T

2 papers

NM_003000.3

p.P49fs

c.145_146fs

1 paper

NM_003000.3

p.D48delFs

c.142delC

2 papers

NM_003000.3

p.D50Y

c.148G>T

1 paper

NM_003000.3

p.P49insFs

c.147dupA

1 paper

NM_003000.3

p.D50H

c.148G>C

1 paper

NM_003000.3

p.D48fs

c.142_143fs

19 papers

NM_003000.3

p.W47*

c.141G>A

1 paper

NM_003000.3

p.D50V

c.149A>T