Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_003000.3

p.F42delFs

c.126delA

Surrounding Variants

1 paper

NM_003000.3

p.F42insFs

c.124_125dupTT

19 papers

NM_003000.3

p.A43P

c.127G>C

1 paper

NM_003000.3

p.A43T

c.127G>A

3 papers

NM_003000.3

p.F42fs

c.124_125fs

1 paper

NM_003000.3

p.F42L

c.126T>G

1 paper

NM_003000.3

p.F42L

c.126T>A

1 paper

NM_003000.3

p.K40_F42delFs

c.119_125del7

1 paper

NM_003000.3

p.K40_A43delFs

c.120_127del8

1 paper

NM_003000.3

p.A43A

c.129C>A

2 papers

NM_003000.3

p.K41insFs

c.122dupA

1 paper

NM_003000.3

p.F42L

c.124T>C

1 paper

NM_003000.3

p.I44fs

c.130_131fs