Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.K41E

c.121A>G

Surrounding Variants

1 paper

NM_003000.3

p.K41Q

c.121A>C

1 paper

NM_003000.3

p.K40insFs

c.120dupG

1 paper

NM_003000.3

p.I39_K40delFs

c.117_120del4

3 papers

NM_003000.3

p.K40N

c.120G>T

4 papers

NM_003000.3

p.K40_K41insFs

c.120_121insC

4 papers

NM_003000.3

p.K40N

c.120G>C

2 papers

NM_003000.3

p.K40K

c.120G>A

1 paper

NM_003000.3

p.K40R

c.119A>G

5 papers

NM_003000.3

p.K40T

c.119A>C

2 papers

NM_003000.3

p.K41insFs

c.122dupA

1 paper

NM_003000.3

p.F42L

c.124T>C

16 papers

NM_003000.3

p.K40E

c.118A>G