Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_003000.3

p.R38delFs

c.112delG

Surrounding Variants

3 papers

NM_003000.3

p.P37_R38insFs

c.111_112dupCC

2 papers

NM_003000.3

p.R38P

c.113G>C

11 papers

NM_003000.3

p.R38H

c.113G>A

5 papers

NM_003000.3

p.R38fs

c.112_113fs

2 papers

NM_003000.3

p.R38R

c.114T>A

1 paper

NM_003000.3

p.R38fs

c.112_113fs

18 papers

NM_003000.3

p.R38C

c.112C>T

1 paper

NM_003000.3

p.R38insFs

c.112_113ins2

2 papers

NM_003000.3

p.A36_P37del2

c.106_110del6

1 paper

NM_003000.3

p.P37L

c.110C>T

1 paper

NM_003000.3

p.A33_A36delFs

c.98_108del11

1 paper

NM_003000.3

p.P37S

c.109C>T