Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_003000.3

p.A34V

c.101C>T

Surrounding Variants

1 paper

NM_003000.3

p.G28_A33del6

c.82_98del18

1 paper

NM_003000.3

p.A33_A34del1

c.98_100delCTG

1 paper

NM_003000.3

p.A33fs

c.97_98fs

1 paper

NM_003000.3

p.A33V

c.98C>T

1 paper

NM_003000.3

p.A33T

c.97G>A

2 papers

NM_003000.3

p.A33fs

c.97_98fs

1 paper

NM_003000.3

p.A32delFs

c.94_95delGC

1 paper

NM_003000.3

p.A36S

c.106G>T

1 paper

NM_003000.3

p.T35insFs

c.105dupA

1 paper

NM_003000.3

p.A36T

c.106G>A

4 papers

NM_003000.3

p.A32V

c.95C>T

1 paper

NM_003000.3

p.A36V

c.107C>T