Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.A32delFs

c.94_95delGC

Surrounding Variants

1 paper

NM_003000.3

p.A33T

c.97G>A

4 papers

NM_003000.3

p.A32V

c.95C>T

1 paper

NM_003000.3

p.A32G

c.95C>G

2 papers

NM_003000.3

p.A32D

c.95C>A

2 papers

NM_003000.3

p.A33fs

c.97_98fs

1 paper

NM_003000.3

p.A32S

c.94G>T

1 paper

NM_003000.3

p.A32T

c.94G>A

1 paper

NM_003000.3

p.A33V

c.98C>T

1 paper

NM_003000.3

p.T31T

c.93A>T

1 paper

NM_003000.3

p.A33fs

c.97_98fs

2 papers

NM_003000.3

p.T31I

c.92C>T

1 paper

NM_003000.3

p.A29_T31Fs

c.86_92delinsGGFs