Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.A29A

c.87C>T

Surrounding Variants

4 papers

NM_003000.3

p.Q30fs

c.88_89fs

1 paper

NM_003000.3

p.Q30*

c.88C>T

3 papers

NM_003000.3

p.A29_Q30ins1

c.87_88insCAG

1 paper

NM_003000.3

p.S26_A29del4

c.76_86del12

1 paper

NM_003000.3

p.A29S

c.85G>T

1 paper

NM_003000.3

p.A29T

c.85G>A

1 paper

NM_003000.3

p.A29fs

c.85_86fs

26 papers

NM_003000.3

p.Q30delFs

c.88delG

4 papers

NM_003000.3

p.Q30fs

c.88_89fs

1 paper

NM_003000.3

p.G28V

c.83G>T

1 paper

NM_003000.3

p.T31A

c.91A>G

1 paper

NM_003000.3

p.Q30ins0

c.88_90dupCAG