Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_003000.3

p.R27R

c.79C>A

Surrounding Variants

47 papers

NM_003000.3

p.R27*

c.79C>T

8 papers

NM_003000.3

p.R27G

c.79C>G

1 paper

NM_003000.3

p.R27fs

c.79_80fs

1 paper

NM_003000.3

p.R27L

c.80G>T

4 papers

NM_003000.3

p.R27Q

c.80G>A

2 papers

NM_003000.3

p.R27delFs

c.79delG

1 paper

NM_003000.3

p.S26fs

c.76_77fs

2 papers

NM_003000.3

p.S26S

c.78C>A

1 paper

NM_003000.3

p.S26Y

c.77C>A

1 paper

NM_003000.3

p.A25_S26delFs

c.73_76del4

1 paper

NM_003000.3

p.R27R

c.81A>G

1 paper

NM_003000.3

p.R27R

c.81A>C