Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.A25V

c.74C>T

Surrounding Variants

3 papers

NM_003000.3

p.A25delFs

c.73delC

4 papers

NM_003000.3

p.A25S

c.73G>T

4 papers

NM_003000.3

p.A25P

c.73G>C

2 papers

NM_003000.3

p.A25T

c.73G>A

3 papers

NM_003000.3

p.A25fs

c.73_74fs

1 paper

NM_003000.3

p.A25fs

c.73_74fs

1 paper

NM_003000.3

p.Q24_A25Splc

c.73-1G>T

2 papers

NM_003000.3

p.Q24_A25Splc

c.73-1G>A

1 paper

NM_003000.3

p.S26Y

c.77C>A

1 paper

NM_003000.3

p.A25_S26delFs

c.73_76del4

2 papers

NM_003000.3

p.Q24_A25Splc

c.73-2A>T

1 paper

NM_003000.3

p.S26fs

c.76_77fs