Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_003000.3

p.C22F

c.65G>T

Surrounding Variants

1 paper

NM_003000.3

p.C22insFs

c.65_66ins4

3 papers

NM_003000.3

p.C22S

c.65G>C

1 paper

NM_003000.3

p.C22Y

c.65G>A

2 papers

NM_003000.3

p.A21insFs

c.63dupC

1 paper

NM_003000.3

p.C22_L23insC

c.64_68ins3

3 papers

NM_003000.3

p.C22S

c.64T>A

1 paper

NM_003000.3

p.L18_A21del4

c.52_62del12

2 papers

NM_003000.3

p.C22fs

c.64_65fs

2 papers

NM_003000.3

p.L23V

c.67C>G

1 paper

NM_003000.3

p.L23delFs

c.67delG

1 paper

NM_003000.3

p.A21T

c.61G>A

1 paper

NM_003000.3

p.L23delFs

c.68delA