Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.G20R

c.58G>A

Surrounding Variants

1 paper

NM_003000.3

p.G20R

c.58G>C

1 paper

NM_003000.3

p.G19delFs

c.57delG

1 paper

NM_003000.3

p.L9_G19del11

c.25_56del33

1 paper

NM_003000.3

p.G20V

c.59G>T

1 paper

NM_003000.3

p.G20E

c.59G>A

1 paper

NM_003000.3

p.G19insFs

c.55_56dupGG

1 paper

NM_003000.3

p.G19fs

c.55_56fs

1 paper

NM_003000.3

p.G19V

c.56G>T

2 papers

NM_003000.3

p.L18insFs

c.53dupT

1 paper

NM_003000.3

p.A21T

c.61G>A

1 paper

NM_003000.3

p.G19S

c.55G>A

4 papers

NM_003000.3

p.L18_G19insFs

c.54_55insC