Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_003000.3

p.T16_L18insFs

c.46_52dup7

Surrounding Variants

4 papers

NM_003000.3

p.L18_G19insFs

c.54_55insC

1 paper

NM_003000.3

p.L18fs

c.52_53fs

2 papers

NM_003000.3

p.L18F

c.52C>T

1 paper

NM_003000.3

p.L18V

c.52C>G

1 paper

NM_003000.3

p.L18_G19insA

c.52_56ins3

2 papers

NM_003000.3

p.L18insFs

c.53dupT

1 paper

NM_003000.3

p.G19S

c.55G>A

1 paper

NM_003000.3

p.G19V

c.56G>T

3 papers

NM_003000.3

p.T17I

c.50C>T

1 paper

NM_003000.3

p.T17N

c.50C>A

1 paper

NM_003000.3

p.T17delFs

c.49delT

1 paper

NM_003000.3

p.G19insFs

c.55_56dupGG