Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

6 papers

NM_003000.3

p.A15_T16insFs

c.45_46insCC

Surrounding Variants

2 papers

NM_003000.3

p.T16A

c.46A>G

2 papers

NM_003000.3

p.T16P

c.46A>C

3 papers

NM_003000.3

p.T16fs

c.46_47fs

1 paper

NM_003000.3

p.T16I

c.47C>T

1 paper

NM_003000.3

p.T16R

c.47C>G

1 paper

NM_003000.3

p.A15fs

c.43_44fs

1 paper

NM_003000.3

p.R12_T16del0

c.35_46del12

1 paper

NM_003000.3

p.A15V

c.44C>T

1 paper

NM_003000.3

p.A15delFs

c.43delC

3 papers

NM_003000.3

p.A6_P14insFs

c.17_42dup26

2 papers

NM_003000.3

p.A15T

c.43G>A

1 paper

NM_003000.3

p.L13_P14del2

c.37_41del6