Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_003000.3

p.A15fs

c.43_44fs

Surrounding Variants

3 papers

NM_003000.3

p.A6_P14insFs

c.17_42dup26

2 papers

NM_003000.3

p.A15T

c.43G>A

1 paper

NM_003000.3

p.L13_P14del2

c.37_41del6

1 paper

NM_003000.3

p.P14insFs

c.40dupC

1 paper

NM_003000.3

p.L7_P14insFs

c.19_41dup23

1 paper

NM_003000.3

p.P14Fs

c.42delinsTCFs

1 paper

NM_003000.3

p.A15V

c.44C>T

1 paper

NM_003000.3

p.A15delFs

c.43delC

4 papers

NM_003000.3

p.P14L

c.41C>T

1 paper

NM_003000.3

p.A15fs

c.43_44fs

1 paper

NM_003000.3

p.L9_L13del5

c.25_38del15

2 papers

NM_003000.3

p.T16A

c.46A>G