Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_003000.3

p.R12P

c.35G>C

Surrounding Variants

4 papers

NM_003000.3

p.R12Q

c.35G>A

2 papers

NM_003000.3

p.R12R

c.36G>T

1 paper

NM_003000.3

p.R12_L13ins2

c.36_37ins6

1 paper

NM_003000.3

p.L7_R12delFs

c.19_35del17

3 papers

NM_003000.3

p.A6_R12delFs

c.17_35del19

2 papers

NM_003000.3

p.R12W

c.34C>T

1 paper

NM_003000.3

p.L9_R11insFs

c.26_33dup8

1 paper

NM_003000.3

p.R12ins1

c.34_35insAAA

1 paper

NM_003000.3

p.R10_R11del0

c.28_33del6

1 paper

NM_003000.3

p.R12insFs

c.35dupG

1 paper

NM_003000.3

p.L13L

c.37T>C

1 paper

NM_003000.3

p.R11R

c.33C>G