Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_003000.3

p.L7fs

c.19_20fs

Surrounding Variants

2 papers

NM_003000.3

p.L7L

c.21C>T

1 paper

NM_003000.3

p.S8insFs

c.22_23insC

1 paper

NM_003000.3

p.A6insFs

c.17_18dupCC

1 paper

NM_003000.3

p.S8P

c.22T>C

1 paper

NM_003000.3

p.L7P

c.20T>C

1 paper

NM_003000.3

p.L7Fs

c.20delinsCCFs

1 paper

NM_003000.3

p.L7H

c.20T>A

3 papers

NM_003000.3

p.L7delFs

c.21delG

1 paper

NM_003000.3

p.L7_S8Fs

c.20_22delinsCFs

1 paper

NM_003000.3

p.A6_L7delFs

c.18_21del4

1 paper

NM_003000.3

p.A3_L7delFs

c.9_19del11

1 paper

NM_003000.3

p.S8fs

c.22_23fs