Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

32 papers

NM_003000.3

p.A6A

c.18C>A

Surrounding Variants

2 papers

NM_003000.3

p.A6fs

c.16_17fs

1 paper

NM_003000.3

p.A6_L7insFs

c.18_19insA

1 paper

NM_003000.3

p.A6delins

c.16_18delinsACA

1 paper

NM_003000.3

p.L7F

c.19C>T

3 papers

NM_003000.3

p.L7V

c.19C>G

1 paper

NM_003000.3

p.L7fs

c.19_20fs

1 paper

NM_003000.3

p.A6delFs

c.16delC

1 paper

NM_003000.3

p.A6insFs

c.17_18dupCC

1 paper

NM_003000.3

p.L7P

c.20T>C

1 paper

NM_003000.3

p.L7Fs

c.20delinsCCFs

1 paper

NM_003000.3

p.L7H

c.20T>A

1 paper

NM_003000.3

p.A3_L7delFs

c.9_19del11