Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.A6S

c.16G>T

Surrounding Variants

1 paper

NM_003000.3

p.V5insFs

c.15dupC

4 papers

NM_003000.3

p.A6T

c.16G>A

2 papers

NM_003000.3

p.A6fs

c.16_17fs

3 papers

NM_003000.3

p.V5insFs

c.14dupT

1 paper

NM_003000.3

p.V5insFs

c.14_15insTG

1 paper

NM_003000.3

p.V5ins1

c.14_15insTTC

1 paper

NM_003000.3

p.V5delFs

c.13_14delAC

1 paper

NM_003000.3

p.A6delFs

c.16delC

1 paper

NM_003000.3

p.V5ins1

c.14_15insCTT

1 paper

NM_003000.3

p.V4insFs

c.12dupG

4 papers

NM_003000.3

p.V5G

c.14T>G

1 paper

NM_003000.3

p.V5A

c.14T>C