Varaico: Literature-Extracted Genetic Variants

SDHB

1,345 papers

RefSeq Summary

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed o...

Pfam Domains

Fer2_3aa 41–144UCSC2Fe-2S iron-sulfur cluster binding domain

Fer4_17aa 167–240UCSC4Fe-4S dicluster domain

Gene Aliases

HGNC Name

succinate dehydrogenase complex iron sulfur subunit B

HGNC Previous Symbols

SDH1; SDH

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003000.3

p.A2E

c.5C>A

Surrounding Variants

5 papers

NM_003000.3

p.A2V

c.5C>T

1 paper

NM_003000.3

p.M1insFs

c.3dupG

1 paper

NM_003000.3

p.A2Fs

c.5delinsAAAFs

1 paper

NM_003000.3

p.A2delins

c.5delinsGAAA

1 paper

NM_003000.3

p.A2fs

c.4_5fs

1 paper

NM_003000.3

p.A2A

c.6G>A

10 papers

NM_003000.3

p.M1I

c.3G>T

2 papers

NM_003000.3

p.M1insFs

c.2dupT

1 paper

NM_003000.3

p.M1insFs

c.1_2dupAT

1 paper

NM_003000.3

p.A3Fs

c.7delinsTGGGTAGGGFs

1 paper

NM_003000.3

p.M1fs

c.1_2fs

1 paper

NM_003000.3

p.M1_A2insFs

c.3_4insA