selenoprotein I

EPT1

KIAA1724

SELI

SEPI

ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)

ethanolaminephosphotransferase 1

Ethanolaminephosphotransferase 1

Selenoprotein I

hEPT1

SelI

The multi-pass transmembrane protein encoded by this gene belongs to the CDP-alcohol phosphatidyltransferase class-I family. It catalyzes the transfer of phosphoethanolamine from CDP-ethanolamine to diacylglycerol to produce phosphatidylethanolamine, which is involved in the formation and maintenance of vesicular membranes, regulation of lipid metabolism, and protein folding. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016].

Varaico: Literature-Extracted Genetic Variants

SELENOI

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Previous Symbol