Varaico: Literature-Extracted Genetic Variants

Gene:SH2B3
Variant:p.D91Y

SH2B3

633 papers

RefSeq Summary

This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative ...

Pfam Domains

Phe_ZIPaa 25–80UCSCPhenylalanine zipper
SH2aa 364–441UCSCSH2 domain

Gene Aliases

HGNC Name

SH2B adaptor protein 3

HGNC Alias Symbols

LNK; IDDM20

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_005475.3
p.D91Y
c.271G>T
Surrounding Variants
1 paper
NM_005475.3
p.D91N
c.271G>A
2 papers
NM_005475.3
p.R90Q
c.269G>A
1 paper
NM_005475.3
p.G93S
c.277G>A
1 paper
NM_005475.3
p.D88N
c.262G>A
1 paper
NM_005475.3
p.D88Y
c.262G>T
1 paper
NM_005475.3
p.R94H
c.281G>A
1 paper
NM_005475.3
p.G95_A102delFs
c.285_304del20
1 paper
NM_005475.3
p.G95_S103del0
c.284_307del24
1 paper
NM_005475.3
p.G86G
c.258C>G
1 paper
NM_005475.3
p.G95G
c.285G>A
1 paper
NM_005475.3
p.P97insFs
c.290dupC
1 paper
NM_005475.3
p.P96T
c.286C>A
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