Varaico: Literature-Extracted Genetic Variants

Gene:SH2B3
Variant:p.H357Y

SH2B3

633 papers

RefSeq Summary

This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative ...

Pfam Domains

Phe_ZIPaa 25–80UCSCPhenylalanine zipper
SH2aa 364–441UCSCSH2 domain

Gene Aliases

HGNC Name

SH2B adaptor protein 3

HGNC Alias Symbols

LNK; IDDM20

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_005475.3
p.H357Y
c.1069C>T
Surrounding Variants
1 paper
NM_005475.3
p.F358insFs
c.1073dupT
1 paper
NM_005475.3
p.S360_W364insFs
c.1078_1091dup14
1 paper
NM_005475.3
p.T355M
c.1064C>T
1 paper
NM_005475.3
p.F358F
c.1074C>T
1 paper
NM_005475.3
p.T355fs
c.1063_1064fs
1 paper
NM_005475.3
p.L359V
c.1075C>G
1 paper
NM_005475.3
p.K354R
c.1061A>G
1 paper
NM_005475.3
p.T355del1
c.1063_1064delACG
1 paper
NM_005475.3
p.L359L
c.1077G>A
1 paper
NM_005475.3
p.K354fs
c.1060_1061fs
1 paper
NM_005475.3
p.S360C
c.1079C>G
3 papers
NM_005475.3
p.S360S
c.1080C>T
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