secreted LY6/PLAUR domain containing 2

Secreted Ly-6/uPAR domain-containing protein 2

Secreted LY6/PLAUR domain-containing protein 2

Secreted Ly-6/uPAR-related protein 2

SLURP-2

This gene encodes a novel, secreted member of the Ly6/uPAR (LU) superfamily of proteins containing the unique three-finger LU domain. This gene is mainly expressed in epithelial cells, including skin and keratinocytes, and is up-regulated in psoriatic skin lesions, suggesting its involvement in the pathophysiology of psoriasis. Alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (LYNX1) generates naturally-occurring transcripts (LYNX1-SLURP2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Sep 2017].

Varaico: Literature-Extracted Genetic Variants

SLURP2

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name