SMAD specific E3 ubiquitin protein ligase 1

KIAA1625

E3 ubiquitin-protein ligase SMURF1

HECT-type E3 ubiquitin transferase SMURF1

SMAD ubiquitination regulatory factor 1

SMAD-specific E3 ubiquitin-protein ligase 1

hSMURF1

This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2010].

Varaico: Literature-Extracted Genetic Variants

SMURF1

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Alias Symbol