Varaico: Literature-Extracted Genetic Variants

SOS1

956 papers

RefSeq Summary

This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding ...

Pfam Domains

RhoGEFaa 211–388UCSCRhoGEF domain

SOS1_NGEF_PHaa 439–544UCSCSOS1/NGEF-like PH domain

RasGEF_Naa 600–717UCSCRasGEF N-terminal motif

RasGEFaa 783–962UCSCRasGEF domain

Gene Aliases

HGNC Name

SOS Ras/Rac guanine nucleotide exchange factor 1

HGNC Previous Symbol

GINGF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005633.4

p.R854P

c.2561G>C

Surrounding Variants

2 papers

NM_005633.4

p.R854Q

c.2561G>A

1 paper

NM_005633.4

p.R854*

c.2560C>T

1 paper

NM_005633.4

p.S853G

c.2557A>G

1 paper

NM_005633.4

p.I856V

c.2566A>G

3 papers

NM_005633.4

p.I856T

c.2567T>C

1 paper

NM_005633.4

p.I856N

c.2567T>A

1 paper

NM_005633.4

p.V852L

c.2554G>T

1 paper

NM_005633.4

p.V852L

c.2554G>C

1 paper

NM_005633.4

p.E857K

c.2569G>A

1 paper

NM_005633.4

p.E857D

c.2571G>T

1 paper

NM_005633.4

p.V851L

c.2551G>T

1 paper

NM_005633.4

p.E857D

c.2571G>C