Varaico: Literature-Extracted Genetic Variants

SOS1

956 papers

RefSeq Summary

This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding ...

Pfam Domains

RhoGEFaa 211–388UCSCRhoGEF domain

SOS1_NGEF_PHaa 439–544UCSCSOS1/NGEF-like PH domain

RasGEF_Naa 600–717UCSCRasGEF N-terminal motif

RasGEFaa 783–962UCSCRasGEF domain

Gene Aliases

HGNC Name

SOS Ras/Rac guanine nucleotide exchange factor 1

HGNC Previous Symbol

GINGF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

6 papers

NM_005633.4

p.L613V

c.1837C>G

Surrounding Variants

1 paper

NM_005633.4

p.T614M

c.1841C>T

1 paper

NM_005633.4

p.Y615C

c.1844A>G

7 papers

NM_005633.4

p.I610T

c.1829T>C

1 paper

NM_005633.4

p.M617V

c.1849A>G

1 paper

NM_005633.4

p.M617T

c.1850T>C

1 paper

NM_005633.4

p.M617I

c.1851G>T

1 paper

NM_005633.4

p.M617I

c.1851G>C

1 paper

NM_005633.4

p.M617I

c.1851G>A

2 papers

NM_005633.4

p.I607T

c.1820T>C

1 paper

NM_005633.4

p.T605N

c.1814C>A

3 papers

NM_005633.4

p.G604V

c.1811G>T

1 paper

NM_005633.4

p.G604A

c.1811G>C