Varaico: Literature-Extracted Genetic Variants

SOS1

956 papers

RefSeq Summary

This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding ...

Pfam Domains

RhoGEFaa 211–388UCSCRhoGEF domain

SOS1_NGEF_PHaa 439–544UCSCSOS1/NGEF-like PH domain

RasGEF_Naa 600–717UCSCRasGEF N-terminal motif

RasGEFaa 783–962UCSCRasGEF domain

Gene Aliases

HGNC Name

SOS Ras/Rac guanine nucleotide exchange factor 1

HGNC Previous Symbol

GINGF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005633.4

p.C470Y

c.1409G>A

Surrounding Variants

1 paper

NM_005633.4

p.C470*

c.1410C>A

1 paper

NM_005633.4

p.I469M

c.1407T>G

1 paper

NM_005633.4

p.M468R

c.1403T>G

1 paper

NM_005633.4

p.M468T

c.1403T>C

1 paper

NM_005633.4

p.L467*

c.1400T>A

1 paper

NM_005633.4

p.L467V

c.1399T>G

1 paper

NM_005633.4

p.N474H

c.1420A>C

2 papers

NM_005633.4

p.G466A

c.1397G>C

1 paper

NM_005633.4

p.N474K

c.1422T>G

1 paper

NM_005633.4

p.N474K

c.1422T>A

1 paper

NM_005633.4

p.D465E

c.1395T>G

1 paper

NM_005633.4

p.D465E

c.1395T>A