Varaico: Literature-Extracted Genetic Variants

SOS1

956 papers

RefSeq Summary

This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding ...

Pfam Domains

RhoGEFaa 211–388UCSCRhoGEF domain

SOS1_NGEF_PHaa 439–544UCSCSOS1/NGEF-like PH domain

RasGEF_Naa 600–717UCSCRasGEF N-terminal motif

RasGEFaa 783–962UCSCRasGEF domain

Gene Aliases

HGNC Name

SOS Ras/Rac guanine nucleotide exchange factor 1

HGNC Previous Symbol

GINGF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005633.4

p.M446L

c.1336A>C

Surrounding Variants

1 paper

NM_005633.4

p.M446L

c.1336A>T

1 paper

NM_005633.4

p.M446T

c.1337T>C

2 papers

NM_005633.4

p.M446I

c.1338G>T

2 papers

NM_005633.4

p.M446I

c.1338G>C

2 papers

NM_005633.4

p.M446I

c.1338G>A

1 paper

NM_005633.4

p.F444del1

c.1330_1331delAAA

1 paper

NM_005633.4

p.L450V

c.1348C>G

1 paper

NM_005633.4

p.C441F

c.1322G>T

26 papers

NM_005633.4

p.C441Y

c.1322G>A

1 paper

NM_005633.4

p.C440insFs

c.1319dupG

1 paper

NM_005633.4

p.T451K

c.1352C>A

1 paper

NM_005633.4

p.C440S

c.1319G>C