Varaico: Literature-Extracted Genetic Variants

SOS1

956 papers

RefSeq Summary

This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding ...

Pfam Domains

RhoGEFaa 211–388UCSCRhoGEF domain

SOS1_NGEF_PHaa 439–544UCSCSOS1/NGEF-like PH domain

RasGEF_Naa 600–717UCSCRasGEF N-terminal motif

RasGEFaa 783–962UCSCRasGEF domain

Gene Aliases

HGNC Name

SOS Ras/Rac guanine nucleotide exchange factor 1

HGNC Previous Symbol

GINGF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_005633.4

p.W432G

c.1294T>G

Surrounding Variants

26 papers

NM_005633.4

p.W432R

c.1294T>C

23 papers

NM_005633.4

p.W432R

c.1294T>A

1 paper

NM_005633.4

p.W432S

c.1295G>C

1 paper

NM_005633.4

p.G431V

c.1292G>T

1 paper

NM_005633.4

p.D430del1

c.1288_1289delATC

38 papers

NM_005633.4

p.E433K

c.1297G>A

1 paper

NM_005633.4

p.K427_D430del0

c.1281_1289del9

1 paper

NM_005633.4

p.E433G

c.1298A>G

1 paper

NM_005633.4

p.E433A

c.1298A>C

1 paper

NM_005633.4

p.D430G

c.1289A>G

1 paper

NM_005633.4

p.D430A

c.1289A>C

30 papers

NM_005633.4

p.G434R

c.1300G>C