Varaico: Literature-Extracted Genetic Variants

SOS1

956 papers

RefSeq Summary

This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding ...

Pfam Domains

RhoGEFaa 211–388UCSCRhoGEF domain

SOS1_NGEF_PHaa 439–544UCSCSOS1/NGEF-like PH domain

RasGEF_Naa 600–717UCSCRasGEF N-terminal motif

RasGEFaa 783–962UCSCRasGEF domain

Gene Aliases

HGNC Name

SOS Ras/Rac guanine nucleotide exchange factor 1

HGNC Previous Symbol

GINGF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

8 papers

NM_005633.4

p.Q61H

c.183A>C

Surrounding Variants

6 papers

NM_005633.4

p.Q61H

c.183A>T

10 papers

NM_005633.4

p.Q61L

c.182A>T

13 papers

NM_005633.4

p.Q61R

c.182A>G

4 papers

NM_005633.4

p.Q61P

c.182A>C

1 paper

NM_005633.4

p.Q61*

c.181C>T

2 papers

NM_005633.4

p.Q61E

c.181C>G

6 papers

NM_005633.4

p.Q61K

c.181C>A

4 papers

NM_005633.4

p.C60S

c.179G>C

2 papers

NM_005633.4

p.C60Y

c.179G>A

1 paper

NM_005633.4

p.C60S

c.178T>A

8 papers

NM_005633.4

p.Q63R

c.188A>G

2 papers

NM_005633.4

p.M58V

c.172A>G