Sp2 transcription factor

KIAA0048

Transcription factor Sp2

This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. [provided by RefSeq, Jul 2008].

Varaico: Literature-Extracted Genetic Variants

SP2

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name

HGNC Alias Symbol