serine peptidase inhibitor Kazal type 9

Serine protease inhibitor Kazal-type 9

Lymphoepithelial Kazal-type-related inhibitor 2

Kazal-type serine protease inhibitor domain

The protein encoded by this gene is a Kazal-type serine protease inhibitor that appears to specifically target kallikrein-related peptidase 5 (KLK5) in the palmo-plantar epidermis. KLK5 is an important initiator of skin desquamation, so the encoded protease inhibitor may regulate skin differentiation in the palms of hands and soles of feet. This cationic protein has also been shown to promote keratinocyte migration by activation of the epidermal growth factor receptor (EGFR). [provided by RefSeq, Dec 2015].

Varaico: Literature-Extracted Genetic Variants

SPINK9

RefSeq Summary

Pfam Domains

Gene Aliases

HGNC Name