Varaico: Literature-Extracted Genetic Variants

SPO11

67 papers

RefSeq Summary

Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalen...

Pfam Domains

SPO11_likeaa 2–44UCSCSPO11 homologue

TP6A_Naa 109–170UCSCType IIB DNA topoisomerase

TOP6A-Spo11_Toprimaa 219–390UCSCTopoisomerase 6 subunit A/Spo11, Toprim domain

Gene Aliases

HGNC Name

SPO11 initiator of meiotic double strand breaks

HGNC Alias Symbols

CT35; SPATA43; TOPVIA; TOPOVIA

Papers

RefSeq ID

Protein change

DNA change

1–12 of 81 variants

6 papers

NM_012444.3

p.R211W

c.631C>T

5 papers

NM_012444.3

p.E186K

c.556G>A

3 papers

NM_012444.3

p.E9K

c.25G>A

3 papers

NM_012444.3

p.R183G

c.547A>G

3 papers

NM_012444.3

p.D277E

c.831T>A

3 papers

NM_012444.3

p.D277E

c.831T>G

2 papers

NM_012444.3

p.K123R

c.368A>G

2 papers

NM_012444.3

p.P306T

c.916C>A

1 paper

NM_012444.3

p.P8T

c.22C>A

1 paper

NM_012444.3

p.P8A

c.22C>G

1 paper

NM_012444.3

p.E9Q

c.25G>C

1 paper

NM_012444.3

p.R18Q

c.53G>A