Varaico: Literature-Extracted Genetic Variants

SPO11

67 papers

RefSeq Summary

Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalen...

Pfam Domains

SPO11_likeaa 2–44UCSCSPO11 homologue

TP6A_Naa 109–170UCSCType IIB DNA topoisomerase

TOP6A-Spo11_Toprimaa 219–390UCSCTopoisomerase 6 subunit A/Spo11, Toprim domain

Gene Aliases

HGNC Name

SPO11 initiator of meiotic double strand breaks

HGNC Alias Symbols

CT35; SPATA43; TOPVIA; TOPOVIA

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_012444.3

p.E9K

c.25G>A

Surrounding Variants

1 paper

NM_012444.3

p.E9Q

c.25G>C

1 paper

NM_012444.3

p.P8T

c.22C>A

1 paper

NM_012444.3

p.P8A

c.22C>G

1 paper

NM_012444.3

p.R18Q

c.53G>A

1 paper

NM_012444.3

p.R20M

c.59G>T

1 paper

NM_012444.3

p.A25T

c.73G>A

1 paper

NM_012444.3

p.E33K

c.97G>A

1 paper

NM_012444.3

p.S44Splc

c.132-1247C>T

1 paper

NM_012444.3

p.S45_E46delFs

c.135_136delTG

1 paper

NM_012444.3

p.E46D

c.138G>C

1 paper

NM_012444.3

p.I55V

c.163A>G

1 paper

NM_012444.3

p.R75_N80insFs

c.224_240dup17