Varaico: Literature-Extracted Genetic Variants

SPO11

67 papers

RefSeq Summary

Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalen...

Pfam Domains

SPO11_likeaa 2–44UCSCSPO11 homologue

TP6A_Naa 109–170UCSCType IIB DNA topoisomerase

TOP6A-Spo11_Toprimaa 219–390UCSCTopoisomerase 6 subunit A/Spo11, Toprim domain

Gene Aliases

HGNC Name

SPO11 initiator of meiotic double strand breaks

HGNC Alias Symbols

CT35; SPATA43; TOPVIA; TOPOVIA

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_012444.3

p.S167R

c.501T>G

Surrounding Variants

1 paper

NM_012444.3

p.N155K

c.465T>A

1 paper

NM_012444.3

p.N155K

c.465T>G

1 paper

NM_012444.3

p.I154T

c.461T>C

1 paper

NM_012444.3

p.S141R

c.423T>A

1 paper

NM_012444.3

p.Y138F

c.413A>T

1 paper

NM_012444.3

p.Y137F

c.410A>T

1 paper

NM_012444.3

p.D135_I136del2

c.403_407del6

1 paper

NM_012444.3

p.K133R

c.398A>G

1 paper

NM_012444.3

p.Q126K

c.376C>A

1 paper

NM_012444.3

p.L124ins1

c.371_372insACA

2 papers

NM_012444.3

p.K123R

c.368A>G

1 paper

NM_012444.3

p.I121_Y122ins1

c.363_364insACA