Varaico: Literature-Extracted Genetic Variants

SPO11

67 papers

RefSeq Summary

Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalen...

Pfam Domains

SPO11_likeaa 2–44UCSCSPO11 homologue

TP6A_Naa 109–170UCSCType IIB DNA topoisomerase

TOP6A-Spo11_Toprimaa 219–390UCSCTopoisomerase 6 subunit A/Spo11, Toprim domain

Gene Aliases

HGNC Name

SPO11 initiator of meiotic double strand breaks

HGNC Alias Symbols

CT35; SPATA43; TOPVIA; TOPOVIA

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_012444.3

p.D279N

c.835G>A

Surrounding Variants

3 papers

NM_012444.3

p.D277E

c.831T>A

3 papers

NM_012444.3

p.D277E

c.831T>G

1 paper

NM_012444.3

p.D277N

c.829G>A

1 paper

NM_012444.3

p.H269_P271delFs

c.805_812del8

1 paper

NM_012444.3

p.L260*

c.779T>A

1 paper

NM_012444.3

p.L260*

c.779T>G

1 paper

NM_012444.3

p.L259P

c.776T>C

1 paper

NM_012444.3

p.T257_R258delFs

c.771_772delAA

1 paper

NM_012444.3

p.T257_R258del2

c.769_773del6

1 paper

NM_012444.3

p.D254Y

c.760G>T

1 paper

NM_012444.3

p.Y289_K290del2

c.865_869del6

1 paper

NM_012444.3

p.Y289N

c.865T>A