Varaico: Literature-Extracted Genetic Variants

Gene:SSH2
Variant:p.R93W

SSH2

58 papers

RefSeq Summary

This gene encodes a protein tyrosine phosphatase that plays a key role in the regulation of actin filaments. The encoded protein dephosphorylates and activates cofilin, which promotes actin filament d...

Pfam Domains

PH_SSH1-like_1staa 103–252UCSCProtein phosphatase Slingshot homolog 1-like, PH domain-like
DEK_Caa 276–329UCSCDEK C terminal domain
DSPcaa 342–472UCSCDual specificity phosphatase, catalytic domain

Gene Aliases

HGNC Name

slingshot protein phosphatase 2

HGNC Alias Symbol

KIAA1725

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_001282129.2
p.R93W
c.277C>T
Surrounding Variants
1 paper
NM_001282129.2
p.S63Splc
c.189-8C>T
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."