Varaico: Literature-Extracted Genetic Variants

STAT1

1,286 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and the...

Pfam Domains

STAT_intaa 2–120UCSCSTAT protein, protein interaction domain

STAT_alphaaa 143–309UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 321–458UCSCSTAT protein, DNA binding domain

STAT_linkeraa 480–558UCSCSignal transducer and activator of transcription, linker domain

SH2aa 573–651UCSCSH2 domain

STAT1_TAZ2bindaa 715–739UCSCSTAT1 TAZ2 binding domain

Gene Aliases

HGNC Name

signal transducer and activator of transcription 1

HGNC Alias Symbols

STAT91; ISGF-3

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_007315.4

p.V457V

c.1371G>A

Surrounding Variants

1 paper

NM_007315.4

p.S459A

c.1375T>G

1 paper

NM_007315.4

p.V456G

c.1367T>G

1 paper

NM_007315.4

p.S459F

c.1376C>T

1 paper

NM_007315.4

p.V455A

c.1364T>C

5 papers

NM_007315.4

p.N460D

c.1378A>G

1 paper

NM_007315.4

p.N460H

c.1378A>C

3 papers

NM_007315.4

p.V455I

c.1363G>A

1 paper

NM_007315.4

p.N460I

c.1379A>T

1 paper

NM_007315.4

p.V461L

c.1381G>C

1 paper

NM_007315.4

p.L453P

c.1358T>C

1 paper

NM_007315.4

p.S462G

c.1384A>G

1 paper

NM_007315.4

p.S462R

c.1384A>C