Varaico: Literature-Extracted Genetic Variants

STAT3

2,222 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and the...

Pfam Domains

STAT_intaa 2–120UCSCSTAT protein, protein interaction domain

STAT_alphaaa 113–281UCSCSTAT transcription factor, coiled-coil domain

STAT_alphaaa 145–313UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 325–464UCSCSTAT protein, DNA binding domain

STAT_linkeraa 486–565UCSCSignal transducer and activator of transcription, linker domain

SH2aa 584–674UCSCSH2 domain

Gene Aliases

HGNC Name

signal transducer and activator of transcription 3

HGNC Alias Symbol

APRF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_139276.3

p.P715Q

c.2144C>A

Surrounding Variants

24 papers

NM_139276.3

p.P715L

c.2144C>T

NM_003150.4

p.P714L

c.2141C>T

1 paper

NM_139276.3

p.P715Splc

c.2144+1G>T

7 papers

NM_139276.3

p.P715Splc

c.2144+1G>A

1 paper

NM_139276.3

p.P715S

c.2143C>T

1 paper

NM_139276.3

p.P715Splc

c.2144+2T>A

14 papers

NM_139276.3

p.T714I

c.2141C>T

11 papers

NM_139276.3

p.T714A

c.2140A>G

14 papers

NM_139276.3

p.V713L

c.2137G>T

14 papers

NM_139276.3

p.V713L

c.2137G>C

8 papers

NM_139276.3

p.V713M

c.2137G>A

1 paper

NM_139276.3

p.C712S

c.2135G>C

1 paper

NM_139276.3

p.C712Y

c.2135G>A