Varaico: Literature-Extracted Genetic Variants

STAT3

2,222 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and the...

Pfam Domains

STAT_intaa 2–120UCSCSTAT protein, protein interaction domain

STAT_alphaaa 113–281UCSCSTAT transcription factor, coiled-coil domain

STAT_alphaaa 145–313UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 325–464UCSCSTAT protein, DNA binding domain

STAT_linkeraa 486–565UCSCSignal transducer and activator of transcription, linker domain

SH2aa 584–674UCSCSH2 domain

Gene Aliases

HGNC Name

signal transducer and activator of transcription 3

HGNC Alias Symbol

APRF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_139276.3

p.K707E

c.2119A>G

Surrounding Variants

1 paper

NM_139276.3

p.K707R

c.2120A>G

1 paper

NM_139276.3

p.L706R

c.2117T>G

1 paper

NM_139276.3

p.L706P

c.2117T>C

1 paper

NM_139276.3

p.L706Q

c.2117T>A

9 papers

NM_139276.3

p.L706M

c.2116C>A

9 papers

NM_139276.3

p.T708S

c.2122A>T

1 paper

NM_139276.3

p.Y705Y

c.2115C>T

9 papers

NM_139276.3

p.T708S

c.2123C>G

1 paper

NM_139276.3

p.Y705*

c.2115C>G

8 papers

NM_139276.3

p.T708N

c.2123C>A

1 paper

NM_139276.3

p.Y705*

c.2115C>A

1 paper

NM_139276.3

p.T708T

c.2124C>G