Varaico: Literature-Extracted Genetic Variants

STAT3

2,222 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and the...

Pfam Domains

STAT_intaa 2–120UCSCSTAT protein, protein interaction domain

STAT_alphaaa 113–281UCSCSTAT transcription factor, coiled-coil domain

STAT_alphaaa 145–313UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 325–464UCSCSTAT protein, DNA binding domain

STAT_linkeraa 486–565UCSCSignal transducer and activator of transcription, linker domain

SH2aa 584–674UCSCSH2 domain

Gene Aliases

HGNC Name

signal transducer and activator of transcription 3

HGNC Alias Symbol

APRF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_139276.3

p.E696K

c.2086G>A

Surrounding Variants

1 paper

NM_139276.3

p.E696delFs

c.2086delC

2 papers

NM_139276.3

p.H694Q

c.2082T>G

2 papers

NM_139276.3

p.H694Q

c.2082T>A

1 paper

NM_139276.3

p.D698Y

c.2092G>T

2 papers

NM_139276.3

p.D698H

c.2092G>C

1 paper

NM_139276.3

p.A697delFs

c.2091delA

1 paper

NM_139276.3

p.D698fs

c.2092_2093fs

1 paper

NM_139276.3

p.Q692L

c.2075A>T

1 paper

NM_139276.3

p.P699del1

c.2095_2096delTGG

1 paper

NM_139276.3

p.Q692E

c.2074C>G

1 paper

NM_139276.3

p.S701R

c.2101A>C

1 paper

NM_139276.3

p.S701delFs

c.2101delT