Varaico: Literature-Extracted Genetic Variants

STAT3

2,222 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and the...

Pfam Domains

STAT_intaa 2–120UCSCSTAT protein, protein interaction domain

STAT_alphaaa 113–281UCSCSTAT transcription factor, coiled-coil domain

STAT_alphaaa 145–313UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 325–464UCSCSTAT protein, DNA binding domain

STAT_linkeraa 486–565UCSCSignal transducer and activator of transcription, linker domain

SH2aa 584–674UCSCSH2 domain

Gene Aliases

HGNC Name

signal transducer and activator of transcription 3

HGNC Alias Symbol

APRF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

24 papers

NM_139276.3

p.K658R

c.1973A>G

Surrounding Variants

10 papers

NM_139276.3

p.K658M

c.1973A>T

40 papers

NM_139276.3

p.K658N

c.1974G>T

1 paper

NM_139276.3

p.K658delins

c.1972_1974delinsAAAAAG

38 papers

NM_139276.3

p.K658N

c.1974G>C

1 paper

NM_139276.3

p.K658delins

c.1972_1974delinsTAT

1 paper

NM_139276.3

p.K658delins

c.1972_1974delinsCAC

2 papers

NM_139276.3

p.K658*

c.1972A>T

8 papers

NM_139276.3

p.K658E

c.1972A>G

3 papers

NM_139276.3

p.Y657ins0

c.1969_1971dupTAT

3 papers

NM_139276.3

p.Y657delFs

c.1971delA

5 papers

NM_139276.3

p.Y657*

c.1971T>G

5 papers

NM_139276.3

p.Y657*

c.1971T>A