Varaico: Literature-Extracted Genetic Variants

STAT3

2,222 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and the...

Pfam Domains

STAT_intaa 2–120UCSCSTAT protein, protein interaction domain

STAT_alphaaa 113–281UCSCSTAT transcription factor, coiled-coil domain

STAT_alphaaa 145–313UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 325–464UCSCSTAT protein, DNA binding domain

STAT_linkeraa 486–565UCSCSignal transducer and activator of transcription, linker domain

SH2aa 584–674UCSCSH2 domain

Gene Aliases

HGNC Name

signal transducer and activator of transcription 3

HGNC Alias Symbol

APRF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

15 papers

NM_139276.3

p.N646K

c.1938C>A

Surrounding Variants

15 papers

NM_139276.3

p.N646K

c.1938C>G

3 papers

NM_139276.3

p.N647Y

c.1939A>T

17 papers

NM_139276.3

p.N647D

c.1939A>G

74 papers

NM_139276.3

p.N647I

c.1940A>T

1 paper

NM_139276.3

p.N647T

c.1940A>C

2 papers

NM_139276.3

p.N647delins

c.1939_1940delinsTT

3 papers

NM_139276.3

p.L645Q

c.1934T>A

11 papers

NM_139276.3

p.Q644del1

c.1930_1931delCTG

1 paper

NM_139276.3

p.M648L

c.1942A>T

1 paper

NM_139276.3

p.M648L

c.1942A>C

1 paper

NM_139276.3

p.L645L

c.1933C>T

1 paper

NM_139276.3

p.Q644H

c.1932G>T