Varaico: Literature-Extracted Genetic Variants

STAT3

2,222 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and the...

Pfam Domains

STAT_intaa 2–120UCSCSTAT protein, protein interaction domain

STAT_alphaaa 113–281UCSCSTAT transcription factor, coiled-coil domain

STAT_alphaaa 145–313UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 325–464UCSCSTAT protein, DNA binding domain

STAT_linkeraa 486–565UCSCSignal transducer and activator of transcription, linker domain

SH2aa 584–674UCSCSH2 domain

Gene Aliases

HGNC Name

signal transducer and activator of transcription 3

HGNC Alias Symbol

APRF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

12 papers

NM_139276.3

p.E638G

c.1913A>G

Surrounding Variants

3 papers

NM_139276.3

p.E638Q

c.1912G>C

14 papers

NM_139276.3

p.P639S

c.1915C>T

17 papers

NM_139276.3

p.P639A

c.1915C>G

7 papers

NM_139276.3

p.P639T

c.1915C>A

13 papers

NM_139276.3

p.V637A

c.1910T>C

4 papers

NM_139276.3

p.P639L

c.1916C>T

3 papers

NM_139276.3

p.P639Q

c.1916C>A

14 papers

NM_139276.3

p.V637L

c.1909G>T

14 papers

NM_139276.3

p.V637L

c.1909G>C

95 papers

NM_139276.3

p.V637M

c.1909G>A

1 paper

NM_139276.3

p.Y640H

c.1918T>C

1 paper

NM_139276.3

p.Y640N

c.1918T>A