Varaico: Literature-Extracted Genetic Variants

STAT3

2,222 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and the...

Pfam Domains

STAT_intaa 2–120UCSCSTAT protein, protein interaction domain

STAT_alphaaa 113–281UCSCSTAT transcription factor, coiled-coil domain

STAT_alphaaa 145–313UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 325–464UCSCSTAT protein, DNA binding domain

STAT_linkeraa 486–565UCSCSignal transducer and activator of transcription, linker domain

SH2aa 584–674UCSCSH2 domain

Gene Aliases

HGNC Name

signal transducer and activator of transcription 3

HGNC Alias Symbol

APRF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_139276.3

p.I634S

c.1901T>G

Surrounding Variants

2 papers

NM_139276.3

p.Q633H

c.1899G>T

2 papers

NM_139276.3

p.Q633H

c.1899G>C

3 papers

NM_139276.3

p.Q633Q

c.1899G>A

1 paper

NM_139276.3

p.Q635E

c.1903C>G

2 papers

NM_139276.3

p.Q635L

c.1904A>T

1 paper

NM_139276.3

p.Q633L

c.1898A>T

2 papers

NM_139276.3

p.Q633*

c.1897C>T

19 papers

NM_139276.3

p.S636F

c.1907C>T

1 paper

NM_139276.3

p.T632I

c.1895C>T

8 papers

NM_139276.3

p.S636Y

c.1907C>A

14 papers

NM_139276.3

p.V637L

c.1909G>T

14 papers

NM_139276.3

p.V637L

c.1909G>C