Varaico: Literature-Extracted Genetic Variants

STAT3

2,222 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and the...

Pfam Domains

STAT_intaa 2–120UCSCSTAT protein, protein interaction domain

STAT_alphaaa 113–281UCSCSTAT transcription factor, coiled-coil domain

STAT_alphaaa 145–313UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 325–464UCSCSTAT protein, DNA binding domain

STAT_linkeraa 486–565UCSCSignal transducer and activator of transcription, linker domain

SH2aa 584–674UCSCSH2 domain

Gene Aliases

HGNC Name

signal transducer and activator of transcription 3

HGNC Alias Symbol

APRF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_139276.3

p.D627delFs

c.1879delC

Surrounding Variants

1 paper

NM_139276.3

p.D627G

c.1880A>G

1 paper

NM_139276.3

p.D627E

c.1881C>G

1 paper

NM_139276.3

p.D627E

c.1881C>A

1 paper

NM_139276.3

p.K626N

c.1878G>T

1 paper

NM_139276.3

p.K626N

c.1878G>C

1 paper

NM_139276.3

p.I628_S629insFs

c.1884_1885insG

1 paper

NM_139276.3

p.E625D

c.1875G>T

1 paper

NM_139276.3

p.E625D

c.1875G>C

1 paper

NM_139276.3

p.S629T

c.1886G>C

1 paper

NM_139276.3

p.G630S

c.1888G>A

2 papers

NM_139276.3

p.V624M

c.1870G>A

4 papers

NM_139276.3

p.W623L

c.1868G>T