Varaico: Literature-Extracted Genetic Variants

STAT3

2,222 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and the...

Pfam Domains

STAT_intaa 2–120UCSCSTAT protein, protein interaction domain

STAT_alphaaa 113–281UCSCSTAT transcription factor, coiled-coil domain

STAT_alphaaa 145–313UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 325–464UCSCSTAT protein, DNA binding domain

STAT_linkeraa 486–565UCSCSignal transducer and activator of transcription, linker domain

SH2aa 584–674UCSCSH2 domain

Gene Aliases

HGNC Name

signal transducer and activator of transcription 3

HGNC Alias Symbol

APRF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

31 papers

NM_139276.3

p.E616G

c.1847A>G

Surrounding Variants

8 papers

NM_139276.3

p.E616V

c.1847A>T

1 paper

NM_139276.3

p.E616A

c.1847A>C

3 papers

NM_139276.3

p.E616Q

c.1846G>C

16 papers

NM_139276.3

p.E616K

c.1846G>A

2 papers

NM_139276.3

p.G617R

c.1849G>C

2 papers

NM_139276.3

p.G617R

c.1849G>A

1 paper

NM_139276.3

p.K615_E616insFs

c.1845_1846insGT

7 papers

NM_139276.3

p.G617V

c.1850G>T

10 papers

NM_139276.3

p.G617E

c.1850G>A

39 papers

NM_139276.3

p.E616del1

c.1846_1847delTTC

5 papers

NM_139276.3

p.K615E

c.1843A>G

1 paper

NM_139276.3

p.G617G

c.1851A>C