Varaico: Literature-Extracted Genetic Variants

STAT3

2,222 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and the...

Pfam Domains

STAT_intaa 2–120UCSCSTAT protein, protein interaction domain

STAT_alphaaa 113–281UCSCSTAT transcription factor, coiled-coil domain

STAT_alphaaa 145–313UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 325–464UCSCSTAT protein, DNA binding domain

STAT_linkeraa 486–565UCSCSignal transducer and activator of transcription, linker domain

SH2aa 584–674UCSCSH2 domain

Gene Aliases

HGNC Name

signal transducer and activator of transcription 3

HGNC Alias Symbol

APRF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_139276.3

p.L608P

c.1823T>C

Surrounding Variants

1 paper

NM_139276.3

p.R609*

c.1825A>T

8 papers

NM_139276.3

p.R609G

c.1825A>G

1 paper

NM_139276.3

p.L607R

c.1820T>G

3 papers

NM_139276.3

p.R609T

c.1826G>C

2 papers

NM_139276.3

p.R609K

c.1826G>A

1 paper

NM_139276.3

p.S599_F606del0

c.1795_1818del24

7 papers

NM_139276.3

p.R609S

c.1827A>T

7 papers

NM_139276.3

p.R609S

c.1827A>C

1 paper

NM_139276.3

p.F606L

c.1818C>G

1 paper

NM_139276.3

p.F606L

c.1818C>A

1 paper

NM_139276.3

p.F606L

c.1816T>C

8 papers

NM_139276.3

p.S611G

c.1831A>G