Varaico: Literature-Extracted Genetic Variants

STAT3

2,222 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and the...

Pfam Domains

STAT_intaa 2–120UCSCSTAT protein, protein interaction domain

STAT_alphaaa 113–281UCSCSTAT transcription factor, coiled-coil domain

STAT_alphaaa 145–313UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 325–464UCSCSTAT protein, DNA binding domain

STAT_linkeraa 486–565UCSCSignal transducer and activator of transcription, linker domain

SH2aa 584–674UCSCSH2 domain

Gene Aliases

HGNC Name

signal transducer and activator of transcription 3

HGNC Alias Symbol

APRF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

8 papers

NM_139276.3

p.N401D

c.1201A>G

Surrounding Variants

1 paper

NM_139276.3

p.G402C

c.1204G>T

1 paper

NM_139276.3

p.G402R

c.1204G>C

1 paper

NM_139276.3

p.G402S

c.1204G>A

1 paper

NM_139276.3

p.G402D

c.1205G>A

1 paper

NM_139276.3

p.S403R

c.1207A>C

1 paper

NM_139276.3

p.S403T

c.1208G>C

1 paper

NM_139276.3

p.S403R

c.1209C>G

1 paper

NM_139276.3

p.S403R

c.1209C>A

1 paper

NM_139276.3

p.E398K

c.1192G>A

1 paper

NM_139276.3

p.L404fs

c.1210_1211fs

2 papers

NM_139276.3

p.S403delFs

c.1209delG

4 papers

NM_139276.3

p.E397_E398insFs

c.1191_1192insG